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Full Chemical Name:UR-144 Systematic IUPAC Name(1-pentylindol-3-yl)- (2,2,3,3-tetramet hylcyclopropyl)methanone CAS Number 1199943-44-6 ChemSpider Number 24634882 Molecular Formula C21H29NO Molecular Mass 311.461 g/mol What is UR-144? Invented by Abbott Laboratories, UR-144 is another addition to our extensive Cannabinoid selection. UR-144 is also known under the names TMCP-018, KM-X1, UR-144, MN-001, and YX-17.UR-144 acts as selective full agonist of the peripheral CB2 receptor, in vitro (outside living organism). UR-144 has a low affinity for the CB1 receptor. UR-144 would be a great addition to researchers concentrating on the peripheral CB1 receptor.
What is UR-144 used for? UR-144 binds fully with a high selectivity to the peripheral CB2 receptor. This means it is useful to researchers conducting in vitro experiments analysing its complete binding profile to the peripheral CB2 receptor. This profiling could include, receptor affinity (potency) and duration of action. UR-144's affinity for the CB2 is Ki 1.8nM however it has 83x lower affinity for the CB1 receptor with a Ki of 150nM. By combusting UR-144 with heat, researchers can increase the surface area of the ligand, enabling the efficient application of ligand to an appropriate receptor infused membrane.
Chemist may choose to use UR-144 as a primary reagent. It may also be useful as a reference sample for NMR, GC/MS, FTIR or HPLC analysis, for both toxicologist and forensic use.
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